Poster

HIGH MOLECULAR WEIGHT INTRAARTICULAR HYALURONIC ACID FOR THE TREATMENT OF KNEE OSTEOARTHRITIS: NETWORK META-ANALYSIS

AUTHORS: Charles D. Hummer, M.D., Felix Angst M.D., Emil Schemitsch, M.D., Craig Whittington, PhD, Colleen Manitt, PhD, Wilson Ngai
CONFERENCE: OARSI 2019
DATE: May 2-5, 2019

2019-OARSI-DRE-Sanofi-HMW-Poster

Purpose:

  • In 2013, the American Academy of Orthopaedic Surgeons (AAOS) clinical practice guideline (CPG) on the treatment of knee osteoarthritis (OA) made a strong recommendation not in favor of the use of intraarticular hyaluronic acid (IAHA) because the improvement in pain, although statistically significant, did not meet the threshold for a minimal clinically important difference.
  • The AAOS CPG, and subsequent publications, suggest there may be clinically important differences in the effectiveness of high versus low molecular weight (MW) IAHA.
  • Given further research published since the CPG, we aimed to examine this issue by performing a network meta-analysis (NMA) on an updated literature search of both direct and indirect evidence.